WP2
Scaffold Fabrication, Design and Characterization
The objective of WP2 is to develop, optimize, and comprehensively characterize advanced electrospun nanofibrous scaffolds that serve as multifunctional wound healing platforms. Building on the MXene complexes from WP1, this work package will:
- Engineer next-generation electrospun and hybrid-spun membranes integrating MXene-PDA-Ab (for targeted antibacterial photothermal therapy) and MXene-PDA-HATMSC (for pro-regenerative signaling), achieving a synergistic antibacterial–regenerative effect.
- Optimize scaffold architecture and material composition to yield biocompatible, mechanically robust membranes with tunable porosity, high surface area, and moisture management properties, supporting cell adhesion, proliferation, and angiogenesis.
- Incorporate controlled release functionality for bioactive components, ensuring sustained therapeutic action and reduced need for dressing changes.
- Perform multi-scale structural and functional characterization (SEM, AFM, XRD, FTIR, conductivity measurements, degradation and wettability studies) to validate scaffold integrity, reproducibility, and readiness for downstream biological testing and preclinical translation.
WP2 will deliver clinically relevant wound dressings with integrated antimicrobial and regenerative functionality, forming the cornerstone of the MX-WOUND therapeutic platform.